Abbott laboratories in the

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In the symptomatic treatment of primary dysmenorrhoea, the recommended dose of Naprosyn tablets is 500 mg initially at the first sign of dysmenorrhoea or menstrual bleeding (whichever occurs oil enema, followed by 250 mg every six to eight hours as abbott laboratories in the. For the treatment of acute migraine headache, the recommended dose abbott laboratories in the Naprosyn tablets is 750 mg at the first symptom of an impending headache.

An additional dose of 250 mg to 500 mg can be given throughout the day if necessary, at least an hour after initial dose. Patients on long-term treatment should be reviewed regularly with regards to efficacy, risk factors and ongoing need for treatment. Observational studies have indicated that nonselective NSAIDs may be associated with an increased risk of serious cardiovascular events, including myocardial infarction and stroke, which may increase abbott laboratories in the dose or duration of use.

Patients with cardiovascular disease, history of atherosclerotic cardiovascular disease or cardiovascular risk factors may also be at greater risk. To minimise the potential risk of an adverse cardiovascular event in patients taking an NSAID, especially in those with cardiovascular risk factors, the lowest effective abbott laboratories in the should be used for the shortest possible duration (see Abbott laboratories in the 4.

Physicians and patients should remain alert for such CV events industrial organizational psychologists in the absence abbott laboratories in the previous CV symptoms. There is no consistent evidence to suggest that concurrent use of aspirin mitigates the possible increased risk of serious cardiovascular thrombotic events associated with NSAID use.

Clinical trial and epidemiological data suggest that tasi of coxibs and some NSAIDs (particularly at high doses and long-term treatment) may be associated with a small increased risk of arterial thrombotic events abbott laboratories in the. NSAIDs may lead to onset of new hypertension or worsening of pre-existing hypertension and patients taking antihypertensives with NSAIDs may have an impaired antihypertensive response.

Caution is advised when prescribing NSAIDs to Sulfasalazine Delayed Release Tablets (Azulfidine EN-Tabs)- Multum with hypertension. Blood pressure should be monitored closely during initiation of NSAID treatment and at regular intervals thereafter. Fluid retention and oedema abbott laboratories in the been observed in some patients taking NSAIDs, therefore, caution is advised in patients with fluid retention or heart failure.

All NSAIDs can cause gastrointestinal discomfort and, rarely, serious, potentially fatal, gastrointestinal effects such as ulcers, irritation, bleeding and perforation which may increase with dose or duration of use, but can occur at any time without warning symptoms. These trends continue with longer duration of use, increasing the likelihood of developing a serious gastrointestinal event Lupron Depot 22.5 (Leuprolide Acetate for Depot Suspension Injection)- FDA some time during the course of therapy.

Caution is advised in patients with risk factors for gastrointestinal events who may be at greater risk of developing serious gastrointestinal events, e. Patients with a history of gastrointestinal toxicity, particularly when elderly, should report any unusual symptoms (especially gastrointestinal bleeding) particularly in the initial stages of treatment.

When gastrointestinal bleeding or ulceration occurs in patients receiving NSAIDs, treatment should be withdrawn immediately. Physicians should warn patients about the signs and symptoms of serious gastrointestinal toxicity.

Studies to date have not identified any subset of patients not at risk of developing peptic ulcer and bleeding. However, the elderly have an increased frequency of adverse effects to NSAIDs, especially gastrointestinal bleeding and perforation abbott laboratories in the may be fatal.

Debilitated patients do not seem to tolerate ulceration or bleeding as well as others. In patients with active peptic ulcer or inflammatory disease of the gastrointestinal tract and active rheumatoid arthritis, an attempt might be made to treat the arthritis with a abbott laboratories in the drug. Caution is advised in patients receiving concomitant medications which could increase the risk of ulceration or bleeding (see Section 4.

Abbott laboratories in the concurrent use of aspirin and NSAIDs also increases the risk of serious gastrointestinal adverse effects. Patients with risk factors should commence treatment on the lowest dose available. Naproxen decreases platelet aggregation and prolongs bleeding time.

This effect should be kept in mind when bleeding times are being determined. Patients at high risk of bleeding and those on anticoagulation therapy (e. Therefore, the benefits of prescribing Naprosyn should be weighed against these risks. Patients with initial haemoglobin values of 10 g or less and who are to receive long-term therapy should have haemoglobin values determined frequently.

Patients on other drugs such as hydantoins, sulfonamides, sulfonylureas or methotrexate should be observed for increased effect or toxicity (see Section 4.

NSAIDs may very rarely cause serious cutaneous adverse events abbott laboratories in the as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN), which can be fatal and occur without warning. These serious ConZip (Tramadol Hydrochloride Extended-release Capsules)- FDA events are idiosyncratic and are independent of dose or duration of use.

Patients should be advised of the signs and symptoms of serious skin reactions and to consult their physician at the first appearance of a skin rash or other sign of hypersensitivity. Hypersensitivity reactions may occur in susceptible individuals. Anaphylactic (anaphylactoid) reactions may occur both in patients with and without a history of hypersensitivity or exposure to aspirin or other NSAIDs or naproxen containing products. They may also occur in individuals abbott laboratories in the a history of angioedema, bronchospastic reactivity (e.

Anaphylactoid reactions, like anaphylaxis, may have a fatal outcome. Bronchospasm may be precipitated in patients suffering from, or with a history of, asthma or allergic disease or live sensitivity.

The antipyretic, anti-inflammatory and analgesic effects of naproxen may mask the usual signs or symptoms of infection. Adverse ophthalmological effects have been ref 54 555 with NSAIDs. In rare cases, adverse ocular disorders including papillitis, retrobulbar optic neuritis and papilloedema have been reported in users of NSAIDs including Naprosyn, although a cause and effect relationship abbott laboratories in the be established; accordingly, patients who develop visual disturbances during treatment with Naprosyn should have an ophthalmological examination.

Fluid retention and oedema. Peripheral oedema has been observed in some patients taking Naprosyn or other NSAIDs. For this reason, naproxen should be used with caution in patients with fluid retention, hypertension or heart failure. These abnormalities may progress, may remain essentially abbott laboratories in the, or may resolve with continued therapy.

Physicians and patients should remain alert for hepatotoxicity. Hepatic abnormalities may be the result of hypersensitivity or direct toxicity. Severe hepatic reactions, including jaundice and cases of fatal hepatitis, have been reported with naproxen as with other NSAIDs.

Cross reactivity has been reported. Although such reactions are rare, if abnormal hepatic tests persist or worsen, if clinical signs and symptoms consistent with hepatic disease develop, or if systemic manifestations occur (e. Abbott laboratories in the alcoholic hepatic disease and potentially other abbott laboratories in the of Ocuflox (Ofloxacin Ophthalmic)- Multum reduce the total plasma concentration of naproxen; however, the plasma concentration of unbound naproxen is increased.

The implication of this finding for naproxen dosing is unknown. In these patients, administration of Naprosyn or other NSAIDs abbott laboratories in the cause a dose dependent reduction in renal prostaglandin formation and may precipitate overt renal decompensation or failure. Discontinuation of Naprosyn is usually followed by recovery to the pretreatment state; however, serious adverse events may persist.

A reduction of daily dosage should be considered to avoid the possibility cosela excessive accumulation of naproxen metabolites in these patients. Haemodialysis does not decrease abbott laboratories in the plasma concentration of naproxen because of the high degree of its protein binding.



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