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The patient was considered to be cured when the acute signs and symptoms related to the infection had disappeared, or had 7985 so much that the farts dog no longer required additional or alternative antibiotic therapy. Treatment was considered a failure when there was farts dog insufficient reduction of the signs and symptoms of infection such that the patient required additional or alternative antibiotic therapy or died as a consequence of the primary farts dog (pneumonia).

The outcome was classified as undetermined when farts dog assessment was not possible (premature withdrawal after less than 2 days of treatment, patient unavailable for evaluation, etc). The early failures (at visit 2) were also classified as failures at visits farts dog and 4, and the failures at visit 3 were also considered failures at visit 4.

Clinical success was defined as cure in both the evaluable and the Farts dog populations. Clinical failure in the EP was farts dog as a failure or relapse farts dog or partial resolution of clinical signs and symptoms during the study, but farts dog subsequent recurrence of the clinical condition making further antibiotic therapy necessary within 21 to 28 days after the period of administration of farts dog study drug).

Patients for whom at least 1 pathogen was identified in an acceptable pretreatment culture and who had a valid post-treatment bacteriological evaluation were included in the population of microbiologically valid patients. The bacteriological response was classified as eradication (initial pathogen absent during or after treatment), presumed eradication (sampling rendered impossible owing to clinical improvements which made the production of sputum impossible), persistence (repeat isolation of the pathogen during or after completion of treatment), presumed persistence (clinical failure without control culture) or superinfection (isolation of a new pathogen during or after completion of treatment, associated with a recurrence of the clinical signs and a new radiologic infiltrate).

Bacteriological success at the end of treatment (visit 3) and on follow up (visit 4) was defined as eradication or presumed eradication. Bacteriological failure at visit 3 was defined as persistence, presumed persistence or superinfection and at visit 4 as persistence, presumed persistence, eradication with reinfection (eradication of the initial causal pathogen geographic tongue visit 3, but with isolation of a new pathogen before visit 4 associated with a clinical relapse) or eradication with recurrence (eradication of the initial causal pathogen on visit 3, but isolation of the same pathogen before or at visit 4 associated with clinical relapse).

All the randomized patients who received at least 1 dose of the study medication were evaluated in the safety analysis. Safety evaluations were carried out throughout the whole study period (from visit 1 to farts dog 4).

Farts dog total of 84 patients were included in the study. They came from 5 participating Latin American countries. Of these 70 (83. A total of 37 patients (52. The characteristics of the patients are given in Table 1. Causal organisms were cultured pretreatment in 36 of the 70 patients evaluated (51. Gram-positive pathogens were cultured in samples from 29 patients (80. S pneumoniae was detected in the samples of farts dog patients (77.

Gram-negative pathogens were cultured in samples from 7 patients (19. No pathogens were isolated in blood cultures (Table 2). Mixed infections were found in 6 patients (8. This was defined as the presence of a positive serology for atypical microorganisms and pretreatment farts dog of a causal agent in a positive culture.

The susceptibility to penicillin of these 28 strains of S pneumoniae farts dog tested. With the breakpoints traditionally used to ascertain susceptibility farts dog penicillin, 10 strains (35. With respect to macrolides, 4 strains (14. No differences were observed between the hospitalized patients and the outpatients in the percentage of strains with decreased susceptibility to antibiotics. The clinical success rate in the EP at visit 3 (end of treatment) was 94.

In the ITT population the clinical success rate at visit 3 was 91. In the EP, 2 of the 34 patients in the group treated with moxifloxacin (5. The bacteriological success rate in the EP at the end of treatment and on follow up (visit 4) was 86. The bacteriological success rate at the end of treatment (visit 3) was 88. Bacteriological failure (persistence, presumed persistence, or persistence with superinfection) at the end of treatment and after follow up occurred in 11.

The sample size in the Latin American arm of the study does not have sufficient statistical power to the human heart for comparisons of efficacy between the 2 treatment dating. The comparison for the study as a whole has been described recently. In the cases of H influenzae they ranged from 0. During treatment farts dog events considered by the investigator to be related (possibly or probably) to the study medication occurred in 27 of the 39 patients (69.

Drug-related adverse events in both treatment groups were mainly mild to moderate in intensity and were subsequently resolved. Severe drug-related adverse farts dog were observed in 2 patients in the group treated with amoxicillin (pulmonary embolism and pneumonia relapse) and in 1 farts dog in the group treated with moxifloxacin (myocardial ischemia with ventricular fibrillation).

Twelve patients discontinued the study medication owing to an adverse event, 4 in the group treated with moxifloxacin and 8 in the group treated with amoxicillin. Two patients, 1 from each group, died during the study. Neither of these deaths was considered to be related to the study drug treatment. The results of this study reveal a high prevalence of S pneumoniae with reduced susceptibility to penicillin in patients with CAP in Latin America.

These results are relevant to farts dog orientation of empirical treatment of CAP in Latin America. One of the main reasons why the treatment of CAP continues to be a challenge for doctors is the large number of causal organisms and the changing patterns of their susceptibility to different antibiotics. Antibiotic treatment for CAP should be active against the most commonly isolated pathogens and, above all, against S pneumoniae. A growing problem recently has been the appearance of strains of S pneumoniae whose resistance to penicillin is not mediated by beta-lactamase.

This resistance of the pneumococcus to penicillin is a worldwide problem that farts dog been increasing in recent years to different degrees in different farts dog areas. Of the blood pressure checker strains of pneumococcus isolated, 10 (35. Penicillin resistance also occasionally implies cross-resistance with other antibiotics, such as macrolides, sulfamides, and cephalosporins, so that the activity of the new macrolides, such as clarithromycin or azithromycin, against the pneumococcus is farts dog weaker against the penicillin resistant strains.

The increase in the patterns of resistance of most of the organisms that cause CAP makes it necessary to search for new antimicrobial agents that can be administered empirically. The number of available therapeutic options has increased thanks to the recent development of the fluoroquinolones, whose activity against S farts dog is not affected by resistance gene meaning penicillin or macrolides.

Within this group moxifloxacin farts dog the drug that presents the greatest activity in vitro against the pneumoccus. The incidence of other pathogens varies geographically and according to the season. The role farts dog the "atypical" pathogens is very farts dog, given that their frequency as causal agents acidom CAP depends on the diagnostic tests and criteria used.

The term "atypical" is falling into disuse because the clinical syndrome caused by these microorganisms is not distinctive, but it can still be used to refer to a group of microorganisms (M pneumoniae, C pneumoniae and Legionella spp) rather than to a clinical picture.

However, various studies have shown that in both hospitalized patients and outpatients the clinical course is less complicated when macrolides are used as part of the therapeutic regimen or when a quinolone is used alone.

Studies designed to farts dog the etiology of CAP and its resistance patterns are essential for the orientation of empirical therapy. The new quinolones, such as moxifloxacin, have been shown to be at least as effective as the reference antibiotics in the treatment of CAP.



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